Beilstein J. Org. Chem.2022,18, 479–485, doi:10.3762/bjoc.18.50
, Nakhonsithammarat 80160, Thailand 10.3762/bjoc.18.50 Abstract Two new sesquiterpenes, trichocitrinovirenes A (1) and B (2), and five known compounds including four structurally related sesquiterpenes and one γ-lactone were isolated from the soil-derived fungus Trichodermacitrinoviride PSU-SPSF346. The structures
. Compound 2 possesses a rare bicyclic sesquiterpene skeleton. The antimicrobial and cytotoxic activities of the isolated compounds were evaluated.
Keywords: antimicrobial activity; cytotoxic activity; γ-lactone; soil-derived fungus; sesquiterpene; Trichodermacitrinoviride; Introduction
The fungus
Trichodermacitrinoviride produces structurally diverse secondary metabolites including diterpenes [1][2], alkaloids [3], sorbicillinoids [4][5], long chain alcohols [6], and cyclonerane sesquiterpenes [7]. Some of them display antibacterial [1][2][7], cytotoxic [3], anti-inflammatory [4], and antimicroalgal
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Graphical Abstract
Figure 1:
Structures of compounds 1–7 isolated from Trichoderma citrinoviride PSU-SPSF346.